Novel bimodal effects of the G-protein tissue transglutaminase on adrenoreceptor signalling

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Novel bimodal effects of the G-protein tissue transglutaminase on adrenoreceptor signalling.

Tissue transglutaminase (tTG) is a novel G-protein that previous studies showed can couple ligand-bound activated alpha(1B) adrenoreceptors to phospholipase C-delta, resulting in phosphoinositide (PI) hydrolysis. In human neuroblastoma SH-SY5Y cells we found that although endogenous tTG can facilitate alpha(1B) adrenoreceptor-stimulated PI hydrolysis, its contribution is minor compared with the...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1999

ISSN: 0264-6021,1470-8728

DOI: 10.1042/bj3430541